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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   PP2Ac / PPP2CA Antibody   

PP2Ac / PPP2CA Antibody

Rabbit Polyclonal Antibody

     
  • IHC - PP2Ac / PPP2CA Antibody ALS16840
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - PP2Ac / PPP2CA Antibody ALS16840
    Western Blot analysis of mouse brain lysates with anti-PP2A alpha and beta antibody
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P67775
Other Accession 5515
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 35594 Da
Dilution ELISA (1:8000), IHC-P (2.5 µg/ml), WB (1:200 - 1:1000),
Additional Information
Gene ID 5515
Other Names PPP2CA, PP2Ac, PP2Calpha, ppp2A1, Protein phosphatase 2A alpha, Replication protein C, PP2CA, RP-C, PP2A-alpha
Target/Specificity PP2A alpha and beta Antibody detects endogenous levels of PP2A alpha and beta protein. Not tested with other proteins.
Reconstitution & Storage PBS, pH 7.4, 0.05% sodium azide. Store at -20°C for up to one year.
PrecautionsPP2Ac / PPP2CA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP2CA
Function PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Cellular Location Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity).
Research Areas
Citations (0)

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Background

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.

References

Stone S.R.,et al.Nucleic Acids Res. 16:11365-11365(1988).
Arino J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4252-4256(1988).
Khew-Goodall Y.,et al.Biochemistry 30:89-97(1991).
Scheidtmann K.H.,et al.Mol. Cell. Biol. 11:1996-2003(1991).
Favre B.,et al.J. Biol. Chem. 269:16311-16317(1994).

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$ 395.00
Cat# ALS16840
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