|Application ||WB, IHC-P, ICC, IHC-Fr|
|Calculated MW||32401 Da|
|Dilution||ICC (1:100 - 1:1000), IHC-P (5 µg/ml), WB (1:500 - 1:3000),|
|Other Names||HSD11B1, 11-beta-HSD1, 11-DH, CORTRD2, HSD11B, HSD11L, SDR26C1, HDL, HSD11|
|Reconstitution & Storage||PBS, pH 7.0, 40% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||HSD11B1 / HSD11B Antibody (aa232-292) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSD11, HSD11L, SDR26C1|
|Function||Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed. Highest expression in liver.|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Tannin G.M.,et al.J. Biol. Chem. 266:16653-16658(1991).
Draper N.,et al.J. Clin. Endocrinol. Metab. 87:4984-4990(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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