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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSD11B1 / HSD11B Antibody (aa232-292)   

HSD11B1 / HSD11B Antibody (aa232-292)

Rabbit Polyclonal Antibody

     
  • IHC - HSD11B1 / HSD11B Antibody (aa232-292) ALS16842
    Anti-HSD11B1 / HSD11B antibody IHC staining of human adrenal.
  • IHC - HSD11B1 / HSD11B Antibody (aa232-292) ALS16842
    Anti-HSD11B1 / HSD11B antibody IHC staining of human liver.
  • ICC - HSD11B1 / HSD11B Antibody (aa232-292) ALS16842
    Immunofluorescence of paraformaldehyde-fixed HeLa using HSD11B1 antibody at 1:200 dilution.
  • WB - HSD11B1 / HSD11B Antibody (aa232-292) ALS16842
    Sample (30 ug of whole cell lysate). A: Hep G2 . 12% SDS PAGE. HSD11B1 antibody diluted at 1:1000.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, IHC-Fr
Primary Accession P28845
Other Accession 3290
Reactivity Human, Sheep
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 32401 Da
Dilution ICC (1:100 - 1:1000), IHC-P (5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 3290
Other Names HSD11B1, 11-beta-HSD1, 11-DH, CORTRD2, HSD11B, HSD11L, SDR26C1, HDL, HSD11
Target/Specificity Human HSD11B1
Reconstitution & Storage PBS, pH 7.0, 40% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsHSD11B1 / HSD11B Antibody (aa232-292) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSD11B1
Synonyms HSD11, HSD11L, SDR26C1
Function Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Cellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein
Tissue Location Widely expressed. Highest expression in liver.
Volume 50 µl
Research Areas
Citations (0)

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Background

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

References

Tannin G.M.,et al.J. Biol. Chem. 266:16653-16658(1991).
Draper N.,et al.J. Clin. Endocrinol. Metab. 87:4984-4990(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16842
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