|Application ||IHC-P, E, RIA|
|Calculated MW||30778 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI|
|Target/Specificity||Recognizes Apolipoprotein A-I (Apo A-I). This product does not cross-react with APO A-II or APO B in competitive RIA.|
|Reconstitution & Storage||PBS, 0.1% sodium azide. Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||APOA1 / Apolipoprotein A 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.|
|Tissue Location||Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.|
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Provided below are standard protocols that you may find useful for product applications.
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Shoulders C.C.,et al.Nucleic Acids Res. 11:2827-2837(1983).
Cheung P.,et al.Nucleic Acids Res. 11:3703-3715(1983).
Karathanasis S.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983).
Seilhamer J.J.,et al.DNA 3:309-317(1984).
Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984).
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