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APOA1 / Apolipoprotein A 1 Antibody

Mouse Monoclonal Antibody

     
  • IHC - APOA1 / Apolipoprotein A 1 Antibody ALS16849
    Anti-APOA1 / Apolipoprotein A 1 antibody IHC staining of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, RIA
Primary Accession P02647
Other Accession 335
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a,k
Calculated MW 30778 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 335
Other Names APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI
Target/Specificity Recognizes Apolipoprotein A-I (Apo A-I). This product does not cross-react with APO A-II or APO B in competitive RIA.
Reconstitution & Storage PBS, 0.1% sodium azide. Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsAPOA1 / Apolipoprotein A 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOA1
Function Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Cellular Location Secreted.
Tissue Location Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
Research Areas
Citations (0)

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Background

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

References

Shoulders C.C.,et al.Nucleic Acids Res. 11:2827-2837(1983).
Cheung P.,et al.Nucleic Acids Res. 11:3703-3715(1983).
Karathanasis S.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983).
Seilhamer J.J.,et al.DNA 3:309-317(1984).
Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984).

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$ 395.00
Cat# ALS16849
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