|Application ||WB, IHC-P, E|
|Calculated MW||17328 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||PFDN5, C-Myc-binding protein Mm-1, C-myc binding protein, MM-1, Myc modulator 1, Myc modulator-1, Prefoldin 5, MM1, PFD5, Prefoldin subunit 5|
|Target/Specificity||Human PFDN5 / MM1|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.|
|Precautions||PFDN5 / MM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.|
|Cellular Location||Isoform 1: Nucleus. Isoform 3: Nucleus.|
|Tissue Location||Highly expressed in pancreas and skeletal muscle and moderately in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.
Mori K.,et al.J. Biol. Chem. 273:29794-29800(1998).
Fujioka Y.,et al.J. Biol. Chem. 276:45137-45144(2001).
Hagio Y.,et al.J. Cell. Biochem. 97:145-155(2006).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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