|Application ||WB, IHC-P|
|Calculated MW||27452 Da|
|Dilution||IHC-P (10 µg/ml), WB (1:500 - 1:3000),|
|Other Names||EMCN, Endomucin-2, EMCN2, Endomucin, MUC-14, Mucin-14, MUC14, Gastric cancer antigen Ga34|
|Target/Specificity||Human EMCN / Endomucin|
|Reconstitution & Storage||PBS, pH 7.0, 40% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||EMCN / Endomucin Antibody (aa4-206) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endothelial sialomucin, also called endomucin or mucin- like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein Note=Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks|
|Tissue Location||Expressed in heart, kidney and lung.|
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Provided below are standard protocols that you may find useful for product applications.
Endothelial sialomucin, also called endomucin or mucin- like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
Kinoshita M.,et al.FEBS Lett. 499:121-126(2001).
Kuhn A.,et al.J. Invest. Dermatol. 119:1388-1393(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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