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HOMER1 / Homer 1 Antibody (aa72-339)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | Q86YM7 |
| Other Accession | 9456 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40277 Da |
| Dilution | ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000), |
| Gene ID | 9456 |
|---|---|
| Other Names | HOMER1, HOMER, Homer homolog 1 (Drosophila), Homer protein homolog 1, HOMER1B, SYN47, Ves-1, Homer-1, HOMER-1B, HOMER1A, HOMER1C |
| Target/Specificity | Human HOMER |
| Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Precautions | HOMER1 / Homer 1 Antibody (aa72-339) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HOMER1 (HGNC:17512) |
|---|---|
| Function | Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). |
| Cellular Location | Cytoplasm. Postsynaptic density. Synapse. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z214}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
References
Xiao B.,et al.Neuron 21:707-716(1998).
Nickels A.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Klugmann M.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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