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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   HOMER1 / Homer 1 Antibody (aa72-339)   

HOMER1 / Homer 1 Antibody (aa72-339)

Rabbit Polyclonal Antibody

     
  • IHC - HOMER1 / Homer 1 Antibody (aa72-339) ALS16881
    Anti-HOMER1 / Homer 1 antibody IHC staining of human brain, cortex.
  • ICC - HOMER1 / Homer 1 Antibody (aa72-339) ALS16881
    Immunofluorescence of methanol-fixed HeLa using Homer antibody at 1:500 dilution.
  • WB - HOMER1 / Homer 1 Antibody (aa72-339) ALS16881
    Homer antibody detects HOMER1 protein by Western blot analysis.
  • WB - HOMER1 / Homer 1 Antibody (aa72-339) ALS16881
    Homer antibody detects HOMER1 protein by Western blot analysis.
  • WB - HOMER1 / Homer 1 Antibody (aa72-339) ALS16881
    Sample (20 ug of whole cell lysate).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q86YM7
Other Accession 9456
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 40277 Da
Dilution ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 9456
Other Names HOMER1, HOMER, Homer homolog 1 (Drosophila), Homer protein homolog 1, HOMER1B, SYN47, Ves-1, Homer-1, HOMER-1B, HOMER1A, HOMER1C
Target/Specificity Human HOMER
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsHOMER1 / Homer 1 Antibody (aa72-339) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HOMER1
Synonyms SYN47
Function Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Cellular Location Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.
Volume 50 µl
Research Areas
Citations (0)

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Background

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

References

Xiao B.,et al.Neuron 21:707-716(1998).
Nickels A.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Klugmann M.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS16881
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