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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MAPK4 / ERK4 Antibody (aa1-326)   

MAPK4 / ERK4 Antibody (aa1-326)

Rabbit Polyclonal Antibody

     
  • IHC - MAPK4 / ERK4 Antibody (aa1-326) ALS16883
    Anti-MAPK4 / ERK4 antibody IHC staining of human small intestine.
  • ICC - MAPK4 / ERK4 Antibody (aa1-326) ALS16883
    Immunofluorescence of paraformaldehyde-fixed HeLa using MAPK4 antibody at 1:200 dilution.
  • WB - MAPK4 / ERK4 Antibody (aa1-326) ALS16883
    Sample (30 ug whole cell lysate). A: H1299. 7.5% SDS PAGE. MAPK4 / ERK4 antibody diluted at 1:1000
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession P31152
Other Accession 5596
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 65922 Da
Dilution ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 5596
Other Names MAPK4, ERK-4, Erk3-related, Erk4, MAP kinase isoform p63, PRKM4, RMNK2, MAP kinase 4, ERK3, MAPK 4, p63-MAPK, p63MAPK
Target/Specificity Human MAPK4 / ERK4
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsMAPK4 / ERK4 Antibody (aa1-326) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAPK4
Synonyms ERK4, PRKM4
Function Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Tissue Location High expression in heart and brain.
Volume 50 µl
Research Areas
Citations (0)

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Background

Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).

References

Gonzalez F.A.,et al.FEBS Lett. 304:170-178(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 395.00
Cat# ALS16883
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