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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SCNN1A / ENaC Apha Antibody (aa182-459)   

SCNN1A / ENaC Apha Antibody (aa182-459)

Rabbit Polyclonal Antibody

     
  • IHC - SCNN1A / ENaC Apha Antibody (aa182-459) ALS16889
    Anti-SCNN1A / ENaC Apha antibody IHC staining of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P37088
Other Accession 6337
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 75704 Da
Dilution IHC-P (7.5 µg/ml),
Additional Information
Gene ID 6337
Other Names SCNN1A, Alpha hENaC, Alpha-NaCH, Alpha-ENaC, ENaCalpha, ENaCa, ENaC alpha, HENaC alpha, Alpha ENaC-2, SCNEA, SCNN1, BESC2
Target/Specificity Human ENaC alpha / SCNN1A
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsSCNN1A / ENaC Apha Antibody (aa182-459) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCNN1A
Synonyms SCNN1
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Cellular Location Apical cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non- ciliated epithelial cells, restricted to apical surfaces
Tissue Location Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart
Volume 50 µl
Research Areas
Citations (0)

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Background

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

References

Voilley N.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:247-251(1994).
McDonald F.J.,et al.Am. J. Physiol. 266:L728-L734(1994).
Ludwig M.,et al.Hum. Genet. 102:576-581(1998).
Chow Y.H.,et al.Pediatr. Res. 46:208-214(1999).
Bangel N.,et al.J. Cyst. Fibros. 7:197-205(2008).

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$ 395.00
Cat# ALS16889
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