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BCL2L10 / Diva Antibody (aa60-153)

Rabbit Polyclonal Antibody

     
  • IHC - BCL2L10 / Diva Antibody (aa60-153) ALS16896
    Anti-BCL2L10 / Diva antibody IHC staining of human tonsil.
    detail
  • ICC - BCL2L10 / Diva Antibody (aa60-153) ALS16896
    Immunofluorescence of paraformaldehyde-fixed A431 using BCL2L10 antibody at 1:200 dilution.
    detail
  • WB - BCL2L10 / Diva Antibody (aa60-153) ALS16896
    Sample (30 ug of whole cell lysate). A: Raji. 12% SDS PAGE. BCL-B / Diva antibody diluted at 1:1000.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q9HD36
Other Accession 10017
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 23204 Da
Dilution ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 10017
Other Names BCL2L10, BCL-B, Apoptosis regulator Bcl-B, BCLB, Bcl2-L-10, Diva not vaccine, Anti-apoptotic protein NrH, Bcl-2-like protein 10, Boo, Boo not bladder, Diva
Target/Specificity Human BCL-B / Diva
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsBCL2L10 / Diva Antibody (aa60-153) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2L10 {ECO:0000303|PubMed:17532299}
Function Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity).
Cellular Location Mitochondrion. Nucleus membrane. Endoplasmic reticulum. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Z0F3}. Note=Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898)
Tissue Location Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.

References

Zhang H.,et al.Hum. Mol. Genet. 10:2329-2339(2001).
Ke N.,et al.J. Biol. Chem. 276:12481-12484(2001).
Aouacheria A.,et al.Oncogene 20:5846-5855(2001).
Zody M.C.,et al.Nature 440:671-675(2006).

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Discontinued
Cat# ALS16896
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