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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CUL5 / Cullin-5 Antibody (aa113-583)   

CUL5 / Cullin-5 Antibody (aa113-583)

Rabbit Polyclonal Antibody

     
  • IHC - CUL5 / Cullin-5 Antibody (aa113-583) ALS16898
    Anti-CUL5 / Cullin-5 antibody IHC staining of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q93034
Other Accession 8065
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 90955 Da
Dilution IHC-P (7.5 µg/ml),
Additional Information
Gene ID 8065
Other Names CUL5, Cullin 5, CUL-5, VACM-1, VACM1, Cullin-5
Target/Specificity Human CUL5 / Cullin-5
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsCUL5 / Cullin-5 Antibody (aa113-583) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CUL5
Synonyms VACM1
Function Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Volume 50 µl
Research Areas
Citations (0)

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Background

Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

References

Byrd P.J.,et al.Genome Res. 7:71-75(1997).
Longo K.A.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
Kanaya K.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16898
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