|Application ||WB, IHC-P|
|Calculated MW||14371 Da|
|Dilution||IHC-P (5 µg/ml), WB (1:500 - 1:3000),|
|Other Names||FABP6, Fatty acid-binding protein 6, GT, I-BALB, IBABP, I-BABP, Ileal lipid-binding protein, ILLBP, I-15P, ILBP, ILBP3, Illeal lipid-binding protein, Intestinal 15 kDa protein, Gastrotropin, I-BAP|
|Target/Specificity||Human I-BABP / FABP6|
|Reconstitution & Storage||0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||I-BABP / FABP6 Antibody (aa1-142) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.|
|Cellular Location||Isoform 1: Cytoplasm.|
|Tissue Location||Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum|
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Provided below are standard protocols that you may find useful for product applications.
Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
Oelkers P.,et al.Biochim. Biophys. Acta 1257:199-202(1995).
Fujita M.,et al.Eur. J. Biochem. 233:406-413(1995).
Fang C.,et al.Cancer Res. 67:9039-9046(2007).
Schmutz J.,et al.Nature 431:268-274(2004).
Barley N.F.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
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