I-BABP / FABP6 Antibody (aa1-142)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | P51161 |
Other Accession | 2172 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 14371 Da |
Dilution | IHC-P (5 µg/ml), WB (1:500 - 1:3000), |
Gene ID | 2172 |
---|---|
Other Names | FABP6, Fatty acid-binding protein 6, GT, I-BALB, IBABP, I-BABP, Ileal lipid-binding protein, ILLBP, I-15P, ILBP, ILBP3, Illeal lipid-binding protein, Intestinal 15 kDa protein, Gastrotropin, I-BAP |
Target/Specificity | Human I-BABP / FABP6 |
Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | I-BABP / FABP6 Antibody (aa1-142) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FABP6 |
---|---|
Synonyms | ILBP, ILLBP |
Function | Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity). |
Cellular Location | [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:P80020}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P50119}; Cytoplasmic side {ECO:0000250|UniProtKB:P50119} |
Tissue Location | Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). |
Volume | 50 µl |
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Background
Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
References
Oelkers P.,et al.Biochim. Biophys. Acta 1257:199-202(1995).
Fujita M.,et al.Eur. J. Biochem. 233:406-413(1995).
Fang C.,et al.Cancer Res. 67:9039-9046(2007).
Schmutz J.,et al.Nature 431:268-274(2004).
Barley N.F.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
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