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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   I-BABP / FABP6 Antibody (aa1-142)   

I-BABP / FABP6 Antibody (aa1-142)

Rabbit Polyclonal Antibody

     
  • IHC - I-BABP / FABP6 Antibody (aa1-142) ALS16899
    Anti-I-BABP / FABP6 antibody IHC staining of human small intestine.
  • WB - I-BABP / FABP6 Antibody (aa1-142) ALS16899
    Sample (30 ug whole cell lysate).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P51161
Other Accession 2172
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 14371 Da
Dilution IHC-P (5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 2172
Other Names FABP6, Fatty acid-binding protein 6, GT, I-BALB, IBABP, I-BABP, Ileal lipid-binding protein, ILLBP, I-15P, ILBP, ILBP3, Illeal lipid-binding protein, Intestinal 15 kDa protein, Gastrotropin, I-BAP
Target/Specificity Human I-BABP / FABP6
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsI-BABP / FABP6 Antibody (aa1-142) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FABP6
Synonyms ILBP, ILLBP
Function Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).
Cellular Location Isoform 1: Cytoplasm {ECO:0000250|UniProtKB:P80020}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P50119}; Cytoplasmic side {ECO:0000250|UniProtKB:P50119}
Tissue Location Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Background

Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.

References

Oelkers P.,et al.Biochim. Biophys. Acta 1257:199-202(1995).
Fujita M.,et al.Eur. J. Biochem. 233:406-413(1995).
Fang C.,et al.Cancer Res. 67:9039-9046(2007).
Schmutz J.,et al.Nature 431:268-274(2004).
Barley N.F.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16899
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