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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   STAM1 / STAM Antibody (aa16-326)   

STAM1 / STAM Antibody (aa16-326)

Rabbit Polyclonal Antibody

     
  • IHC - STAM1 / STAM Antibody (aa16-326) ALS16901
    Anti-STAM1 / STAM antibody IHC staining of human brain, cortex.
  • WB - STAM1 / STAM Antibody (aa16-326) ALS16901
    Sample (30 ug of whole cell lysate).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q92783
Other Accession 8027
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 59180 Da
Dilution IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 8027
Other Names STAM, STAM-1, HSE1 homolog, STAM1
Target/Specificity Human STAM1 / STAM
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsSTAM1 / STAM Antibody (aa16-326) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAM
Synonyms STAM1
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Cellular Location Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Ubiquitously expressed.
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

References

Takeshita T.,et al.Biochem. Biophys. Res. Commun. 225:1035-1039(1996).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Steen H.,et al.J. Biol. Chem. 277:1031-1039(2002).
Asao H.,et al.J. Biol. Chem. 272:32785-32791(1997).
Tanaka N.,et al.J. Biol. Chem. 274:19129-19135(1999).

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$ 395.00
Cat# ALS16901
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