RNF114 / ZNF313 Antibody (aa1-228)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC |
---|---|
Primary Accession | Q9Y508 |
Other Accession | 55905 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 25694 Da |
Dilution | ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000), |
Gene ID | 55905 |
---|---|
Other Names | RNF114, PSORS12, Ring finger protein 114, Zinc finger protein 313, ZNF228, ZNF313, Zinc finger protein 228 |
Target/Specificity | Human RNF114 |
Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | RNF114 / ZNF313 Antibody (aa1-228) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RNF114 |
---|---|
Synonyms | ZNF228, ZNF313 |
Function | E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.
References
Ma Y.-X.,et al.Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:230-237(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
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