|Application ||WB, IHC-P, ICC|
|Calculated MW||25694 Da|
|Dilution||ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),|
|Other Names||RNF114, PSORS12, Ring finger protein 114, Zinc finger protein 313, ZNF228, ZNF313, Zinc finger protein 228|
|Reconstitution & Storage||0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||RNF114 / ZNF313 Antibody (aa1-228) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.
Ma Y.-X.,et al.Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:230-237(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
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