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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRAP1 / HSP75 Antibody   

TRAP1 / HSP75 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - TRAP1 / HSP75 Antibody ALS16907
    Anti-TRAP1 / HSP75 antibody IHC staining of human colon.
  • WB - TRAP1 / HSP75 Antibody ALS16907
    Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE TRAP1 antibody diluted at 1:3000
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q12931
Other Accession 10131
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 80110 Da
Dilution IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 10131
Other Names TRAP1, HSP 75, HSP75, HSP90L, TNFR-associated protein 1, TRAP-1
Target/Specificity Human TRAP1
Reconstitution & Storage PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal. Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
PrecautionsTRAP1 / HSP75 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRAP1
Synonyms HSP75
Function Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Cellular Location Mitochondrion. Mitochondrion inner membrane Mitochondrion matrix
Tissue Location Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
Volume 50 µl
Research Areas
Citations (0)

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Background

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

References

Simmons A.D.,et al.Hum. Mol. Genet. 8:2155-2164(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Song H.Y.,et al.J. Biol. Chem. 270:3574-3581(1995).

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$ 395.00
Cat# ALS16907
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