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MTBP Antibody

Rabbit Polyclonal Antibody

     
  • IHC - MTBP Antibody ALS16908
    Anti-MTBP antibody IHC staining of human kidney.
  • WB - MTBP Antibody ALS16908
    Sample (30 ug of whole cell lysate) A: Jurkat B: THP-1 C: HL-60 5% SDS PAGE MTBP antibody...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q96DY7
Other Accession 27085
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 102193 Da
Dilution IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 27085
Other Names MTBP, Mdm2-binding protein, MDM2BP, HMTBP
Target/Specificity Human MTBP
Reconstitution & Storage PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal. Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
PrecautionsMTBP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTBP
Function Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Volume 50 µl
Research Areas
Citations (0)

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Background

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Brady M.,et al.Mol. Cell. Biol. 25:545-553(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 395.00
Cat# ALS16908
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