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MTBP Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q96DY7 |
| Other Accession | 27085 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 102193 Da |
| Dilution | IHC-P (7.5 µg/ml), WB (1:500 - 1:3000), |
| Gene ID | 27085 |
|---|---|
| Other Names | MTBP, Mdm2-binding protein, MDM2BP, HMTBP |
| Target/Specificity | Human MTBP |
| Reconstitution & Storage | PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal. Aliquot and freeze at -20° C. Avoid freeze-thaw cycles. |
| Precautions | MTBP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTBP |
|---|---|
| Function | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2- dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Brady M.,et al.Mol. Cell. Biol. 25:545-553(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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