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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GOLPH3 Antibody   

GOLPH3 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - GOLPH3 Antibody ALS16914
    Anti-GOLPH3 antibody IHC staining of human kidney.
  • WB - GOLPH3 Antibody ALS16914
    Sample (50 ug of whole cell lysate) A: mouse lung 10% SDS PAGE GOLPH3 antibody diluted at 1:3000
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9H4A6
Other Accession 64083
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 33811 Da
Dilution IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 64083
Other Names GOLPH3, Coat protein GPP34, Coat-protein, Golgi protein, Golgi phosphoprotein 3, GPP34, Golgi-associated protein, GOPP1, MIDAS
Target/Specificity Human/Mouse GOLPH3.
Reconstitution & Storage PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal. Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
PrecautionsGOLPH3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GOLPH3
Synonyms GPP34
Function Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.
Cellular Location Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane. Endosome. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes.
Tissue Location Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal muscle fibers
Volume 50 µl
Research Areas
Citations (0)

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Background

Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.

References

Bell A.W.,et al.J. Biol. Chem. 276:5152-5165(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nakashima-Kamimura N.,et al.J. Cell Sci. 118:5357-5367(2005).

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$ 395.00
Cat# ALS16914
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