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WC1 / ATP7B Antibody (aa3-21, clone S62-29)

Mouse Monoclonal Antibody

     
  • IHC - WC1 / ATP7B Antibody (aa3-21, clone S62-29) ALS16924
    Anti-WC1 / ATP7B antibody IHC staining of human small intestine.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P35670
Other Accession 540
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names S62-29
Calculated MW 157263 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 540
Other Names ATP7B, Copper-transporting ATPase 2, WC1, Wilson disease, PWD, WD, Copper pump 2, WND
Target/Specificity Detects ~160kD in rat brain membrane preparations.
Reconstitution & Storage PBS, pH 7.4, 0.09% sodium azide, 50% glycerol. Store at -20°C.
PrecautionsWC1 / ATP7B Antibody (aa3-21, clone S62-29) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP7B
Synonyms PWD, WC1, WND
Function Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome Note=Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). [Isoform 2]: Cytoplasm
Tissue Location Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues
Research Areas
Citations (0)
citation

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Background

Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.

References

Petrukhin K.,et al.Hum. Mol. Genet. 3:1647-1656(1994).
Carlini E.J.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).
Oh W.J.,et al.Biochem. Biophys. Res. Commun. 259:206-211(1999).
Bull P.C.,et al.Nat. Genet. 5:327-337(1993).

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Discontinued
Cat# ALS16924
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