|Application ||WB, IHC-P, IP|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||157263 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||ATP7B, Copper-transporting ATPase 2, WC1, Wilson disease, PWD, WD, Copper pump 2, WND|
|Target/Specificity||Detects ~160kD in rat brain membrane preparations.|
|Reconstitution & Storage||PBS, pH 7.4, 0.09% sodium azide, 50% glycerol. Store at -20°C.|
|Precautions||WC1 / ATP7B Antibody (aa3-21, clone S62-29) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PWD, WC1, WND|
|Function||Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi- pass membrane protein. Late endosome Note=Predominantly found in the trans-Golgi network (TGN) Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). Not redistributed to the plasma membrane in response to elevated copper levels. Isoform 2: Cytoplasm|
|Tissue Location||Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver The cleaved form WND/140 kDa is found in liver cell lines and other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Petrukhin K.,et al.Hum. Mol. Genet. 3:1647-1656(1994).
Carlini E.J.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).
Oh W.J.,et al.Biochem. Biophys. Res. Commun. 259:206-211(1999).
Bull P.C.,et al.Nat. Genet. 5:327-337(1993).
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