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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KCNMB4 Antibody (aa86-140)   

KCNMB4 Antibody (aa86-140)

Rabbit Polyclonal Antibody

     
  • IHC - KCNMB4 Antibody (aa86-140) ALS16932
    Anti-KCNMB2 antibody IHC staining of human brain, cortex.
  • WB - KCNMB4 Antibody (aa86-140) ALS16932
    Human Vascular Smooth Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - KCNMB4 Antibody (aa86-140) ALS16932
    Western blot of MaxiK (K119) pAb in extracts from HepG2 cells.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q86W47
Other Accession 27345
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 23949 Da
Dilution IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 27345
Other Names KCNMB4, BK beta 4, BK channel subunit beta-4, BKbeta4, Hbeta4, K(VCA)beta-4, Slowpoke beta 4, Maxi K channel subunit beta-4, Maxi K beta 4, Slo-beta-4
Target/Specificity Human KCNMB4
Reconstitution & Storage PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsKCNMB4 Antibody (aa86-140) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNMB4
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.
Volume 50 µl
Research Areas
Citations (0)

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Background

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.

References

Meera P.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000).
Behrens R.,et al.FEBS Lett. 474:99-106(2000).
Brenner R.,et al.J. Biol. Chem. 275:6453-6461(2000).
Weiger T.M.,et al.J. Neurosci. 20:3563-3570(2000).
Jin P.,et al.J. Biol. Chem. 277:10014-10020(2002).

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$ 395.00
Cat# ALS16932
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