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BHMT Antibody (clone 3E11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, Flo |
|---|---|
| Primary Accession | Q93088 |
| Other Accession | 635 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | 3E11 |
| Calculated MW | 44998 Da |
| Dilution | Flo (1:100), IF (1:100), IHC-P (10 µg/ml), WB (1:500), |
| Gene ID | 635 |
|---|---|
| Other Names | BHMT, BHMT1 |
| Target/Specificity | Human BHMT |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | BHMT Antibody (clone 3E11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BHMT {ECO:0000303|PubMed:8798461} |
|---|---|
| Function | Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:O09171}. Nucleus {ECO:0000250|UniProtKB:O09171} Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. {ECO:0000250|UniProtKB:O09171} |
| Tissue Location | Found exclusively in liver and kidney. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
References
Garrow T.A.,et al.J. Biol. Chem. 271:22831-22838(1996).
Park E.I.,et al.J. Biol. Chem. 274:7816-7824(1999).
Sunden S.L.F.,et al.Arch. Biochem. Biophys. 345:171-174(1997).
Millian N.S.,et al.Arch. Biochem. Biophys. 356:93-98(1998).
Evans J.C.,et al.Structure 10:1159-1171(2002).
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