|Application ||WB, IHC, IHC-P, IF|
|Calculated MW||19330 Da|
|Dilution||IF (1:50 - 1:200), IHC (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000),|
|Other Names||SRSF3, SRp20, Pre-mRNA-splicing factor SRP20, SFRS3|
|Target/Specificity||Human SRSF3 / SRP20|
|Reconstitution & Storage||PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||SRSF3 / SRP20 Antibody (aa120-170) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific.|
|Cellular Location||Nucleus. Cytoplasm|
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May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific.
Zahler A.M.,et al.Genes Dev. 6:837-847(1992).
Liu W.L.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
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