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SRSF3 / SRP20 Antibody (aa120-170)

Rabbit Polyclonal Antibody

     
  • IHC - SRSF3 / SRP20 Antibody (aa120-170) ALS16949
    Anti-SRSF3 / SRP20 antibody IHC staining of human brain, cerebellum.
    detail
  • WB - SRSF3 / SRP20 Antibody (aa120-170) ALS16949
    Western blot of SRp20 (F151) pAb in extracts from HeLa.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IHC-P, IF
Primary Accession P84103
Other Accession 6428
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 19330 Da
Dilution IF (1:50 - 1:200), IHC (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 6428
Other Names SRSF3, SRp20, Pre-mRNA-splicing factor SRP20, SFRS3
Target/Specificity Human SRSF3 / SRP20
Reconstitution & Storage PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsSRSF3 / SRP20 Antibody (aa120-170) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SRSF3
Synonyms SFRS3, SRP20
Function Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA- binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A- containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific (PubMed:17036044).
Cellular Location Nucleus. Nucleus speckle. Cytoplasm. Note=Recruited to nuclear speckles following interaction with YTHDC1.
Research Areas
Citations (0)
citation

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Background

May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific.

References

Zahler A.M.,et al.Genes Dev. 6:837-847(1992).
Liu W.L.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 467.50
Cat# ALS16949
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