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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MYD88 Antibody (clone 1B4)   

MYD88 Antibody (clone 1B4)

Mouse Monoclonal Antibody

     
  • IHC - MYD88 Antibody (clone 1B4) ALS16959
    Anti-MYD88 antibody IHC staining of human brain, cortex.
  • IHC - MYD88 Antibody (clone 1B4) ALS16959
    Anti-MYD88 antibody IHC staining of human pancreas.
  • IF - MYD88 Antibody (clone 1B4) ALS16959
    Anti-MYD88 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently...
  • WB - MYD88 Antibody (clone 1B4) ALS16959
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MYD88...
  • FC - MYD88 Antibody (clone 1B4) ALS16959
    Flow cytometry of HeLa cells, using anti-MYD88 antibody (Red), compared to a nonspecific...
  • FC - MYD88 Antibody (clone 1B4) ALS16959
    HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid...
  • FC - MYD88 Antibody (clone 1B4) ALS16959
    Flow cytometry of Jurkat cells, using anti-MYD88 antibody (Red), compared to a nonspecific...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, Flo
Primary Accession Q99836
Other Accession 4615
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 1B4
Calculated MW 33233 Da
Dilution Flo (1:100), IF (1:100), IHC-P (10 µg/ml), WB (1:2000),
Additional Information
Gene ID 4615
Other Names MYD88, MYD88D
Target/Specificity Human MYD88
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsMYD88 Antibody (clone 1B4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYD88
Function Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Cellular Location Cytoplasm
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

References

Hardiman G.,et al.Oncogene 13:2467-2475(1996).
Bonnert T.P.,et al.FEBS Lett. 402:81-84(1997).
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS16959
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