|Application ||IHC-P, E|
|Calculated MW||187148 Da|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml),|
|Other Names||C3, AHUS5, ARMD9, Complement component C3, CPAMD1, Complement C3, ASP, Complement component 3|
|Target/Specificity||Human Complement C3. This antibody is expected to recognize the C3 alpha chain, C3b alpha chain and the C3c alpha chain fragment 2.|
|Reconstitution & Storage||Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.|
|Precautions||Complement C3 Antibody (aa1580-1592) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation.|
|Tissue Location||Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods|
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Provided below are standard protocols that you may find useful for product applications.
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation.
de Bruijn M.H.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:708-712(1985).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Baldo A.,et al.J. Clin. Invest. 92:1543-1547(1993).
Hugli T.E.,et al.J. Biol. Chem. 250:8293-8301(1975).
Oxvig C.,et al.J. Biol. Chem. 270:13645-13651(1995).
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