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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CHTOP / FOP Antibody (C-Terminus, clone KT64)   

CHTOP / FOP Antibody (C-Terminus, clone KT64)

Rat Monoclonal Antibody

     
  • IHC - CHTOP / FOP Antibody (C-Terminus, clone KT64) ALS16973
    Anti-CHTOP / FOP antibody IHC staining of human breast.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, IP
Primary Accession Q9Y3Y2
Other Accession 26097
Reactivity Human, Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names KT64
Calculated MW 26397 Da
Dilution ICC (1:100), IHC-P (10 µg/ml), WB (1:1000),
Additional Information
Gene ID 26097
Other Names CHTOP, C1orf77, Chromatin target of PRMT1, DKFZP547E1010, FOP, Friend of PRMT1 protein, Pp7704, SRAG, SRAG-3, SRAG-5, FL-SRAG, RP1-178F15.2
Target/Specificity Mouse CHTOP / FOP
Reconstitution & Storage PBS, 0.1% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCHTOP / FOP Antibody (C-Terminus, clone KT64) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHTOP
Synonyms C1orf77, FOP
Function Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5- hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP- methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).
Cellular Location Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:23826332}
Tissue Location Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789).
Research Areas
Citations (0)

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Background

Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

References

Xu X.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS16973
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