|Application ||WB, IHC-P, ICC, IP|
|Calculated MW||26397 Da|
|Dilution||ICC (1:100), IHC-P (10 µg/ml), WB (1:1000),|
|Other Names||CHTOP, C1orf77, Chromatin target of PRMT1, DKFZP547E1010, FOP, Friend of PRMT1 protein, Pp7704, SRAG, SRAG-3, SRAG-5, FL-SRAG, RP1-178F15.2|
|Target/Specificity||Mouse CHTOP / FOP|
|Reconstitution & Storage||PBS, 0.1% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CHTOP / FOP Antibody (C-Terminus, clone KT64) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur.|
|Tissue Location||Expressed in an erythroid progenitor cell line derived from peripheral blood.|
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Provided below are standard protocols that you may find useful for product applications.
Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Xu X.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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