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NCL / Nucleolin Antibody (clone 4E2)

Mouse Monoclonal Antibody

     
  • IHC - NCL / Nucleolin Antibody (clone 4E2) ALS16979
    Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - NCL / Nucleolin Antibody (clone 4E2) ALS16979
    Lane1:Jurkat; Lant2: Hela; Lane3: WR19L; Lane4: Rat-1
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, Flo
Primary Accession P19338
Other Accession 4691
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 4E2
Calculated MW 76614 Da
Dilution Flo (5 - 10 µg/ml), ICC (1 - 10 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 4691
Other Names NCL, Nucleolin, C23, Protein C23
Target/Specificity Human Nucleolin
Reconstitution & Storage PBS, pH 7.2, 50% glycerol. Store at -20°C.
PrecautionsNCL / Nucleolin Antibody (clone 4E2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCL
Function Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
Cellular Location Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Volume 50 µl
Citations (0)

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Background

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

References

Srivastava M.,et al.FEBS Lett. 250:99-105(1989).
Srivastava M.,et al.J. Biol. Chem. 265:14922-14931(1990).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Krantz S.,et al.Biochim. Biophys. Acta 1266:109-112(1995).

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$ 395.00
Cat# ALS16979
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