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UBN1 / Ubinuclein 1 Antibody (aa161-210)

Rabbit Polyclonal Antibody

     
  • IHC - UBN1 / Ubinuclein 1 Antibody (aa161-210) ALS16982
    Anti-UBN1 / Ubinuclein 1 antibody IHC staining of human skin.
  • IF - UBN1 / Ubinuclein 1 Antibody (aa161-210) ALS16982
    Immunofluorescence of A549 cells, using Ubinuclein Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession Q9NPG3
Other Accession 29855
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 121520 Da
Dilution ELISA (1:10000), IF (1:100 - 1:500), IHC-P (10 µg/ml),
Additional Information
Gene ID 29855
Other Names UBN1, HIRA-binding protein, Protein VT4, VT, Ubinuclein-1, VT4, Ubinuclein 1
Target/Specificity Ubinuclein Antibody detects endogenous levels of total Ubinuclein protein.
Reconstitution & Storage PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C.
PrecautionsUBN1 / Ubinuclein 1 Antibody (aa161-210) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBN1
Function Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly.
Cellular Location Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis
Tissue Location Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
Volume 50 µl
Research Areas
Citations (0)

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Background

Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly.

References

Aho S.,et al.J. Cell Biol. 148:1165-1176(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Tesmer V.,et al.Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16982
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