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CASP9 / Caspase 9 Antibody (aa299-318)

Rabbit Polyclonal Antibody

     
  • IHC - CASP9 / Caspase 9 Antibody (aa299-318) ALS16984
    Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - CASP9 / Caspase 9 Antibody (aa299-318) ALS16984
    Lane1: SGC-7901 cell lysate(80 µg); Lane2: ECL cell lysate (80 µg); Lane3: Jurkat celllysate(70 µg); Caspase-9: 46kDa
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P55211
Other Accession 842
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 46281 Da
Dilution IHC-P (2.5 µg/ml), WB (1:1000),
Additional Information
Gene ID 842
Other Names CASP9, APAF3, CASPASE-9c, ICE-LAP6, MCH6, ICE-like apoptotic protease 6, APAF-3, Apoptotic protease Mch-6, CASP-9, Caspase 9, Caspase-9, PPP1R56
Target/Specificity This Polyclonal antibody is directed against human Caspase-9 protein. The product was purified from serum by protein A chromatography.
Reconstitution & Storage PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.
PrecautionsCASP9 / Caspase 9 Antibody (aa299-318) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP9
Synonyms MCH6
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
Tissue Location Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).

References

Duan H.,et al.J. Biol. Chem. 271:16720-16724(1996).
Srinivasula S.M.,et al.J. Biol. Chem. 271:27099-27106(1996).
Hadano S.,et al.Mamm. Genome 10:757-760(1999).
Srinivasula S.M.,et al.Cancer Res. 59:999-1002(1999).
Izawa M.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16984
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