HNP-4 / DEFA4 Antibody (aa27-76)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | P12838 |
Other Accession | 1669 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 10504 Da |
Dilution | ELISA (1:10000), IHC-P (20 µg/ml), |
Gene ID | 1669 |
---|---|
Other Names | DEFA4, DEF4, Corticostatin, HNP-4, HP-4, HP4, Defensin, alpha 4, Neutrophil defensin 4 |
Target/Specificity | Defensin alpha 4 antibody detects endogenous levels of Defensin alpha 4. |
Reconstitution & Storage | PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C. |
Precautions | HNP-4 / DEFA4 Antibody (aa27-76) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DEFA4 (HGNC:2763) |
---|---|
Function | Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram- positive bacteria and fungi (PubMed:2500436, PubMed:2501794, PubMed:15317502, PubMed:15616305, PubMed:30658057). Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro) (PubMed:2500436, PubMed:2501794, PubMed:15317502, PubMed:15616305, PubMed:17088326, PubMed:30658057). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef (PubMed:15620707, PubMed:30658057). Protects blood cells against infection with HIV-1 (in vitro) (PubMed:15620707). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro) (PubMed:30658057). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) (PubMed:2843187). |
Cellular Location | Secreted {ECO:0000250|UniProtKB:Q01523}. Cytoplasmic vesicle, secretory vesicle. Note=Stored as mature peptide in neutrophil granules. |
Tissue Location | Expressed in neutrophils (at protein level) (PubMed:2843187, PubMed:2500436, PubMed:2501794). Expressed in bone marrow (PubMed:8469233). |
Volume | 50 µl |
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Background
Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.
References
Palfree R.G.E.,et al.Mol. Endocrinol. 7:199-205(1993).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Singh A.,et al.Biochem. Biophys. Res. Commun. 155:524-529(1988).
Wilde C.G.,et al.J. Biol. Chem. 264:11200-11203(1989).
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