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HNP-4 / DEFA4 Antibody (aa27-76)

Rabbit Polyclonal Antibody

     
  • IHC - HNP-4 / DEFA4 Antibody (aa27-76) ALS16987
    Anti-HNP-4 / DEFA4 antibody IHC staining of human spleen.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P12838
Other Accession 1669
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 10504 Da
Dilution ELISA (1:10000), IHC-P (20 µg/ml),
Additional Information
Gene ID 1669
Other Names DEFA4, DEF4, Corticostatin, HNP-4, HP-4, HP4, Defensin, alpha 4, Neutrophil defensin 4
Target/Specificity Defensin alpha 4 antibody detects endogenous levels of Defensin alpha 4.
Reconstitution & Storage PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C.
PrecautionsHNP-4 / DEFA4 Antibody (aa27-76) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DEFA4 (HGNC:2763)
Function Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram- positive bacteria and fungi (PubMed:2500436, PubMed:2501794, PubMed:15317502, PubMed:15616305, PubMed:30658057). Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro) (PubMed:2500436, PubMed:2501794, PubMed:15317502, PubMed:15616305, PubMed:17088326, PubMed:30658057). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef (PubMed:15620707, PubMed:30658057). Protects blood cells against infection with HIV-1 (in vitro) (PubMed:15620707). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro) (PubMed:30658057). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) (PubMed:2843187).
Cellular Location Secreted {ECO:0000250|UniProtKB:Q01523}. Cytoplasmic vesicle, secretory vesicle. Note=Stored as mature peptide in neutrophil granules.
Tissue Location Expressed in neutrophils (at protein level) (PubMed:2843187, PubMed:2500436, PubMed:2501794). Expressed in bone marrow (PubMed:8469233).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.

References

Palfree R.G.E.,et al.Mol. Endocrinol. 7:199-205(1993).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Singh A.,et al.Biochem. Biophys. Res. Commun. 155:524-529(1988).
Wilde C.G.,et al.J. Biol. Chem. 264:11200-11203(1989).

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Discontinued
Cat# ALS16987
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