|Application ||WB, IHC-P, E|
|Calculated MW||24704 Da|
|Dilution||ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000),|
|Other Names||SERTAD1, CDK4-binding protein p34SEI, SEI-1, SERTA domain containing 1, TRIP-Br1, CDK4-binding protein p34SEI1, SEI1|
|Target/Specificity||SEI-1 antibody detects endogenous levels of SEI-1.|
|Reconstitution & Storage||PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C.|
|Precautions||SERTAD1 / TRIP-Br1 / SEI-1 Antibody (aa168-217) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.|
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Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.
Sugimoto M.,et al.Genes Dev. 13:3027-3033(1999).
Hsu S.-I.,et al.EMBO J. 20:2273-2285(2001).
Cheong J.K.,et al.J. Biol. Chem. 283:11661-11676(2008).
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