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ABCD4 Antibody (aa98-147)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O14678 |
| Other Accession | 5826 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 68597 Da |
| Dilution | ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 5826 |
|---|---|
| Other Names | ABCD4, ABC41, EST352188, p70R, PMP70-related protein, MAHCJ, p79R, PMP69, PXMP1-L, PXMP1L |
| Target/Specificity | ABCD4 Antibodyantibody detects endogenous levels of ABCD4. |
| Reconstitution & Storage | PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C. |
| Precautions | ABCD4 Antibody (aa98-147) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCD4 (HGNC:68) |
|---|---|
| Synonyms | PXMP1L |
| Function | Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner (PubMed:22922874, PubMed:33845046, PubMed:28572511, PubMed:31467407). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Targeted by LMBRD1 lysosomal chaperone to the lysosomal membrane. |
| Tissue Location | Ubiquitous. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.
References
Holzinger A.,et al.Biochem. Biophys. Res. Commun. 237:152-157(1997).
Holzinger A.,et al.FEBS Lett. 426:238-242(1998).
Shani N.,et al.Hum. Mol. Genet. 6:1925-1931(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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