SLC22A5 / OCTN2 Antibody (aa282-331)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | O76082 |
Other Accession | 6584 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 62752 Da |
Dilution | ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 6584 |
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Other Names | SLC22A5, CDSP, OCTN2VT, OCTN2, UST2 |
Target/Specificity | SLC22A5 Antibodyantibody detects endogenous levels of SLC22A5. |
Reconstitution & Storage | PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C. |
Precautions | SLC22A5 / OCTN2 Antibody (aa282-331) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC22A5 (HGNC:10969) |
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Function | Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:10525100, PubMed:10966938, PubMed:17509700, PubMed:20722056, PubMed:33124720). Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3 (PubMed:10454528, PubMed:10525100, PubMed:10966938). In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from Bacillus Subtilis wich induces cytoprotective heat shock proteins contributing to intestinal homeostasis (PubMed:18005709). May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Note=In intestinal cells, apical expression is induced by TNF. Localized to the basal membrane of Sertoli cells (PubMed:35307651). |
Tissue Location | Strongly expressed in kidney, skeletal muscle, heart and placenta (PubMed:10454528). Primarily expressed by surface epithelial cells of the colon (at protein level) (PubMed:18005709) Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells (PubMed:10454528). In testis, localized to Sertoli cell basal membranes, peritubular myoid cells and Leydig cells (PubMed:35307651) |
Volume | 50 µl |
Provided below are standard protocols that you may find useful for product applications.
Background
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
References
Wu X.,et al.Biochem. Biophys. Res. Commun. 246:589-595(1998).
Tamai I.,et al.J. Biol. Chem. 273:20378-20382(1998).
Nezu J.,et al.Nat. Genet. 21:91-94(1999).
Maekawa S.,et al.Biochim. Biophys. Acta 1773:1000-1006(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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