|Application ||WB, IHC-P, E|
|Calculated MW||62752 Da|
|Dilution||ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000),|
|Other Names||SLC22A5, CDSP, OCTN2VT, OCTN2, UST2|
|Target/Specificity||SLC22A5 Antibodyantibody detects endogenous levels of SLC22A5.|
|Reconstitution & Storage||PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C.|
|Precautions||SLC22A5 / OCTN2 Antibody (aa282-331) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells|
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Provided below are standard protocols that you may find useful for product applications.
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Wu X.,et al.Biochem. Biophys. Res. Commun. 246:589-595(1998).
Tamai I.,et al.J. Biol. Chem. 273:20378-20382(1998).
Nezu J.,et al.Nat. Genet. 21:91-94(1999).
Maekawa S.,et al.Biochim. Biophys. Acta 1773:1000-1006(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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