|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||173232 Da|
|Dilution||ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000),|
|Other Names||ARHGEF12, KIAA0382, LARG, PRO2792, Leukemia-associated RhoGEF|
|Target/Specificity||ARHGEF12 Antibodyantibody detects endogenous levels of ARHGEF12.|
|Reconstitution & Storage||PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C.|
|Precautions||ARHGEF12 Antibody (aa435-484) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.|
|Cellular Location||Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation|
|Tissue Location||Ubiquitously expressed. Isoform 2 is found in jejunum and testis|
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May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Kourlas P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:2145-2150(2000).
Nagase T.,et al.DNA Res. 4:141-150(1997).
Ohara O.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Fukuhara S.,et al.FEBS Lett. 485:183-188(2000).
Taya S.,et al.J. Cell Biol. 155:809-820(2001).
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