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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ARHGEF12 Antibody (aa435-484)   

ARHGEF12 Antibody (aa435-484)

Rabbit Polyclonal Antibody

     
  • IHC - ARHGEF12 Antibody (aa435-484) ALS16999
    Anti-ARHGEF12 antibody IHC staining of human liver.
  • WB - ARHGEF12 Antibody (aa435-484) ALS16999
    Western blot of the lysates from HUVEC cells using ARHGEF12 antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9NZN5
Other Accession 23365
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 173232 Da
Dilution ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 23365
Other Names ARHGEF12, KIAA0382, LARG, PRO2792, Leukemia-associated RhoGEF
Target/Specificity ARHGEF12 Antibodyantibody detects endogenous levels of ARHGEF12.
Reconstitution & Storage PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C.
PrecautionsARHGEF12 Antibody (aa435-484) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGEF12
Synonyms KIAA0382, LARG
Function May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Cellular Location Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation
Tissue Location Ubiquitously expressed. Isoform 2 is found in jejunum and testis
Volume 50 µl
Research Areas
Citations (0)

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Background

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.

References

Kourlas P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:2145-2150(2000).
Nagase T.,et al.DNA Res. 4:141-150(1997).
Ohara O.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Fukuhara S.,et al.FEBS Lett. 485:183-188(2000).
Taya S.,et al.J. Cell Biol. 155:809-820(2001).

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$ 395.00
Cat# ALS16999
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