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ARHGEF12 Antibody (aa435-484)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NZN5 |
| Other Accession | 23365 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 173232 Da |
| Dilution | ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 23365 |
|---|---|
| Other Names | ARHGEF12, KIAA0382, LARG, PRO2792, Leukemia-associated RhoGEF |
| Target/Specificity | ARHGEF12 Antibodyantibody detects endogenous levels of ARHGEF12. |
| Reconstitution & Storage | PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C. |
| Precautions | ARHGEF12 Antibody (aa435-484) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGEF12 |
|---|---|
| Synonyms | KIAA0382, LARG |
| Function | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. |
| Cellular Location | Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation. |
| Tissue Location | Ubiquitously expressed. Isoform 2 is found in jejunum and testis |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
References
Kourlas P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:2145-2150(2000).
Nagase T.,et al.DNA Res. 4:141-150(1997).
Ohara O.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Fukuhara S.,et al.FEBS Lett. 485:183-188(2000).
Taya S.,et al.J. Cell Biol. 155:809-820(2001).
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