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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SLC22A16 Antibody (aa101-150)   

SLC22A16 Antibody (aa101-150)

Rabbit Polyclonal Antibody

     
  • IHC - SLC22A16 Antibody (aa101-150) ALS17005
    Anti-SLC22A16 antibody IHC staining of human testis.
  • IHC - SLC22A16 Antibody (aa101-150) ALS17005
    Anti-SLC22A16 antibody IHC staining of human adrenal.
  • WB - SLC22A16 Antibody (aa101-150) ALS17005
    SLC22A16 antibody western blot of HepG2 cell lysate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q86VW1
Other Accession 85413
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 64614 Da
Dilution IHC-P (10 µg/ml), WB (2.5 µg/ml),
Additional Information
Gene ID 85413
Other Names SLC22A16, Carnitine transporter 2, CT2, Flipt 2, FLIPT2, OKB1, OCT6, WUGSC:RG331P03.1, DJ261K5.1, OAT6, Organic cation transporter 6
Target/Specificity Human SLC22A16
Reconstitution & Storage Lyophilized from PBS with 2% sucrose. Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSLC22A16 Antibody (aa101-150) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC22A16
Synonyms OCT6
Function High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis
Tissue Location Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.
Volume 50 µl
Research Areas
Citations (0)

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Background

High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.

References

Eraly S.A.,et al.Biochem. Biophys. Res. Commun. 297:1159-1166(2002).
Gong S.,et al.Exp. Hematol. 30:1162-1169(2002).
Enomoto A.,et al.J. Biol. Chem. 277:36262-36271(2002).
Okabe M.,et al.Biochem. Biophys. Res. Commun. 333:754-762(2005).
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 450.00
Cat# ALS17005
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