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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   COL8A1 / Collagen VIII Alpha 1 Antibody (aa575-743)   

COL8A1 / Collagen VIII Alpha 1 Antibody (aa575-743)

Rabbit Polyclonal Antibody

     
  • IHC - COL8A1 / Collagen VIII Alpha 1 Antibody (aa575-743) ALS17010
    Human Spleen, Vessels: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - COL8A1 / Collagen VIII Alpha 1 Antibody (aa575-743) ALS17010
    Western blot of recombinant COL8A1 / Collagen VIII.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P27658
Other Accession 1295
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 73364 Da
Dilution ELISA (1:100 - 1:200), IHC-P (1:100), WB (1:100 - 1:400),
Additional Information
Gene ID 1295
Other Names COL8A1, Collagen VIII Alpha 1, Endothelial collagen, C3orf7, Collagen alpha-1(VIII) chain, Collagen, type VIII, alpha 1
Target/Specificity Human COL8A1 / Collagen VIII
Reconstitution & Storage PBS, pH 7.4, 0.02% sodium azide, 50% glycerol. Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot to smaller portions and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
PrecautionsCOL8A1 / Collagen VIII Alpha 1 Antibody (aa575-743) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COL8A1
Synonyms C3orf7
Function Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
Cellular Location Secreted, extracellular space, extracellular matrix, basement membrane
Tissue Location Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells.
Volume 50 µl
Research Areas
Citations (0)

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Background

Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

References

Muragaki Y.,et al.Eur. J. Biochem. 197:615-622(1991).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kittelberger R.,et al.Connect. Tissue Res. 24:303-318(1990).
Kittelberger R.,et al.Biochim. Biophys. Acta 1139:295-299(1992).

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$ 395.00
Cat# ALS17010
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