|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat, Pig, Dog|
|Calculated MW||11676 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||HMGA1, High mobility group protein A1, High mobility group protein R, HMG-R, Hmg-i, HMGIY, High mobility group AT-hook 1, HMG-I(Y), HMGA1A|
|Target/Specificity||Human HMGIY / HMGA1|
|Reconstitution & Storage||PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||HMGIY / HMGA1 Antibody (aa1-53) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.|
|Cellular Location||Nucleus. Chromosome.|
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Provided below are standard protocols that you may find useful for product applications.
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Eckner R.,et al.Nucleic Acids Res. 17:5947-5959(1989).
Johnson K.R.,et al.Mol. Cell. Biol. 9:2114-2123(1989).
Friedmann M.,et al.Nucleic Acids Res. 21:4259-4267(1993).
Nagpal S.,et al.J. Biol. Chem. 274:22563-22568(1999).
Mungall A.J.,et al.Nature 425:805-811(2003).
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