|Application ||WB, IHC-P|
|Calculated MW||36966 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||CTSK, Cathepsin K, Cathepsin K (pycnodysostosis), Cathepsin O1, Cathepsin O2, Cathepsin X, CTSO2, PKND, Procathepsin K, PYCD, Cathepsin O, CTS02, CTSO1|
|Target/Specificity||Human CTSK / Cathepsin K.|
|Reconstitution & Storage||0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||CTSK / Cathepsin K Antibody (aa1-101) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.|
|Tissue Location||Predominantly expressed in osteoclasts (bones)|
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Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Shi G.-P.,et al.FEBS Lett. 357:129-134(1995).
Inaoka T.,et al.Biochem. Biophys. Res. Commun. 206:89-96(1995).
Li Y.,et al.J. Bone Miner. Res. 10:1197-1202(1995).
Broemme D.,et al.Biol. Chem. Hoppe-Seyler 376:379-384(1995).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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