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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   OGG1 Antibody (aa1-312)   

OGG1 Antibody (aa1-312)

Rabbit Polyclonal Antibody

     
  • IHC - OGG1 Antibody (aa1-312) ALS17014
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O15527
Other Accession 4968
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 38782 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 4968
Other Names OGG1, 8-oxoguanine DNA glycosylase, AP lyase, HMMH, N-glycosylase/DNA lyase, HOGG1, OGH1, OGG1 type 1f, MMH, MUTM
Target/Specificity Human OGG1.
Reconstitution & Storage 0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsOGG1 Antibody (aa1-312) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OGG1
Synonyms MMH, MUTM, OGH1
Function DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.
Cellular Location Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells Isoform 2A: Mitochondrion.
Tissue Location Ubiquitous.
Volume 50 µl
Research Areas
Citations (0)

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Background

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.

References

Aburatani H.,et al.Cancer Res. 57:2151-2156(1997).
Rosenquist T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997).
Roldan-Arjona T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8016-8020(1997).
Radicella J.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8010-8015(1997).
Lu R.,et al.Curr. Biol. 7:397-407(1997).

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$ 395.00
Cat# ALS17014
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