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SMURF1 Antibody (aa309-402)

Rabbit Polyclonal Antibody

     
  • IHC - SMURF1 Antibody (aa309-402) ALS17016
    Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9HCE7
Other Accession 57154
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 86114 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 57154
Other Names SMURF1, E3 ubiquitin ligase SMURF1, KIAA1625, HSMURF1
Target/Specificity Human SMURF1
Reconstitution & Storage PBS, pH 7, 40% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsSMURF1 Antibody (aa309-402) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMURF1
Synonyms KIAA1625
Function E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in melanocytes (PubMed:23999003).
Volume 50 µl
Research Areas
Citations (0)

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Background

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.

References

Nagase T.,et al.DNA Res. 7:273-281(2000).
Liang M.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Scherer S.W.,et al.Science 300:767-772(2003).

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$ 395.00
Cat# ALS17016
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