DHPS Antibody (aa51-100)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P49366 |
Other Accession | 1725 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 40971 Da |
Dilution | ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 1725 |
---|---|
Other Names | DHPS, Deoxyhypusine synthase, DS, DHS, MIG13, Migration-inducing gene 13 |
Target/Specificity | DHPS Antibody detects endogenous levels of total DHPS protein. |
Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
Precautions | DHPS Antibody (aa51-100) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DHPS |
---|---|
Synonyms | DS |
Function | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
References
Joe Y.A.,et al.J. Biol. Chem. 270:22386-22392(1995).
Bevec D.,et al.FEBS Lett. 378:195-198(1996).
Yan Y.P.,et al.Biochem. J. 315:429-434(1996).
Mantuano E.,et al.Gene 215:153-157(1998).
Yu W.,et al.Genome Res. 7:353-358(1997).
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