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DHPS Antibody (aa51-100)

Rabbit Polyclonal Antibody

     
  • IHC - DHPS Antibody (aa51-100) ALS17026
    Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • IHC - DHPS Antibody (aa51-100) ALS17026
    Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • WB - DHPS Antibody (aa51-100) ALS17026
    Western blot of extracts from NIH-3T3 cells, using DHPS Antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P49366
Other Accession 1725
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 40971 Da
Dilution ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 1725
Other Names DHPS, Deoxyhypusine synthase, DS, DHS, MIG13, Migration-inducing gene 13
Target/Specificity DHPS Antibody detects endogenous levels of total DHPS protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsDHPS Antibody (aa51-100) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DHPS
Synonyms DS
Function Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

References

Joe Y.A.,et al.J. Biol. Chem. 270:22386-22392(1995).
Bevec D.,et al.FEBS Lett. 378:195-198(1996).
Yan Y.P.,et al.Biochem. J. 315:429-434(1996).
Mantuano E.,et al.Gene 215:153-157(1998).
Yu W.,et al.Genome Res. 7:353-358(1997).

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Discontinued
Cat# ALS17026
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