|Application ||WB, IHC-P, E|
|Calculated MW||156267 Da|
|Dilution||ELISA (1:100 - 1:200), IHC-P (1:100), WB (1:100 - 1:400),|
|Other Names||CNTNAP1, CASPR, Caspr1, Contactin associated protein 1, CNTNAP, Contactin-associated protein 1, Neurexin IV, Neurexin-4, Neurexin 4, NRXN4, p190|
|Target/Specificity||Human CNTNAP1 / CASPR / p190|
|Reconstitution & Storage||PBS, pH 7.4, 0.02% sodium azide, 50% glycerol. Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot to smaller portions and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.|
|Precautions||CNTNAP1 / CASPR / p190 Antibody (aa926-1190) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis|
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Provided below are standard protocols that you may find useful for product applications.
Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.
Peles E.,et al.EMBO J. 16:978-988(1997).
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