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CNTNAP1 / CASPR / p190 Antibody (aa926-1190)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P78357 |
| Other Accession | 8506 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 156267 Da |
| Dilution | ELISA (1:100 - 1:200), IHC-P (1:100), WB (1:100 - 1:400), |
| Gene ID | 8506 |
|---|---|
| Other Names | CNTNAP1, CASPR, Caspr1, Contactin associated protein 1, CNTNAP, Contactin-associated protein 1, Neurexin IV, Neurexin-4, Neurexin 4, NRXN4, p190 |
| Target/Specificity | Human CNTNAP1 / CASPR / p190 |
| Reconstitution & Storage | PBS, pH 7.4, 0.02% sodium azide, 50% glycerol. Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot to smaller portions and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles. |
| Precautions | CNTNAP1 / CASPR / p190 Antibody (aa926-1190) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNTNAP1 |
|---|---|
| Synonyms | CASPR, NRXN4 |
| Function | Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:O54991} |
| Tissue Location | Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.
References
Peles E.,et al.EMBO J. 16:978-988(1997).
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