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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ARF6 Antibody (aa84-113)   

ARF6 Antibody (aa84-113)

Rabbit Polyclonal Antibody

     
  • IHC - ARF6 Antibody (aa84-113) ALS17032
    Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - ARF6 Antibody (aa84-113) ALS17032
    Western blot of ARF6 Antibody (Center) in T47D,MCF-7 cell line and mouse bladder tissue lysates...
  • WB - ARF6 Antibody (aa84-113) ALS17032
    Western blot of ARF6 (arrow) using rabbit polyclonal ARF6 Antibody (Center).
  • FC - ARF6 Antibody (aa84-113) ALS17032
    ARF6 Antibody (Center) flow cytometry of CEM cells (bottom histogram) compared to a negative...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession P62330
Other Accession 382
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 20082 Da
Dilution Flo (1:10 - 1:50), IHC-P (5 µg/ml), WB (1:1000),
Additional Information
Gene ID 382
Other Names ARF6, ADP-ribosylation factor 6
Target/Specificity Human ARF6
Reconstitution & Storage PBS, 0.09% sodium azide. Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsARF6 Antibody (aa84-113) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARF6
Function GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
Cellular Location Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cell projection, filopodium membrane; Lipid-anchor. Midbody. Cytoplasm. Cleavage furrow. Note=Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles.
Tissue Location Ubiquitous, with higher levels in heart, substantia nigra, and kidney.
Research Areas
Citations (0)

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Background

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

References

Tsuchiya M.,et al.J. Biol. Chem. 266:2772-2777(1991).
Lebeda R.A.,et al.DNA Cell Biol. 22:737-741(2003).
Mao M.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS17032
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