|Application ||WB, IHC-P|
|Calculated MW||55628 Da|
|Dilution||IHC-P (5 - 10 µg/ml),|
|Other Names||CYP2C9, Cytochrome P450 PB-1, Cytochrome P-450MP, CYP2C10, CYPIIC9, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, p450IIC9, S-mephenytoin 4-hydroxylase, CPC9, CYP2C|
|Target/Specificity||Human CYP2C9 / Cytochrome P450 2C9.|
|Reconstitution & Storage||0.1 M Tris-glycine, pH 7, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||CYP2C9 / Cytochrome P450 2C9 Antibody (aa210-490) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Meehan R.R.,et al.Am. J. Hum. Genet. 42:26-37(1988).
Kimura S.,et al.Nucleic Acids Res. 15:10053-10054(1987).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.