|Application ||WB, IHC-P|
|Calculated MW||55628 Da|
|Dilution||IHC-P (5 - 10 µg/ml),|
|Other Names||CYP2C9, Cytochrome P450 PB-1, Cytochrome P-450MP, CYP2C10, CYPIIC9, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, p450IIC9, S-mephenytoin 4-hydroxylase, CPC9, CYP2C|
|Target/Specificity||Human CYP2C9 / Cytochrome P450 2C9.|
|Reconstitution & Storage||0.1 M Tris-glycine, pH 7, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||CYP2C9 / Cytochrome P450 2C9 Antibody (aa210-490) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Meehan R.R.,et al.Am. J. Hum. Genet. 42:26-37(1988).
Kimura S.,et al.Nucleic Acids Res. 15:10053-10054(1987).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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