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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYP2C9 / Cytochrome P450 2C9 Antibody (aa210-490)   

CYP2C9 / Cytochrome P450 2C9 Antibody (aa210-490)

Rabbit Polyclonal Antibody

     
  • IHC - CYP2C9 / Cytochrome P450 2C9 Antibody (aa210-490) ALS17035
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P11712
Other Accession 1559
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 55628 Da
Dilution IHC-P (5 - 10 µg/ml),
Additional Information
Gene ID 1559
Other Names CYP2C9, Cytochrome P450 PB-1, Cytochrome P-450MP, CYP2C10, CYPIIC9, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, p450IIC9, S-mephenytoin 4-hydroxylase, CPC9, CYP2C
Target/Specificity Human CYP2C9 / Cytochrome P450 2C9.
Reconstitution & Storage 0.1 M Tris-glycine, pH 7, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsCYP2C9 / Cytochrome P450 2C9 Antibody (aa210-490) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP2C9
Synonyms CYP2C10
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Volume 50 µl
Research Areas
Citations (0)

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Background

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.

References

Meehan R.R.,et al.Am. J. Hum. Genet. 42:26-37(1988).
Kimura S.,et al.Nucleic Acids Res. 15:10053-10054(1987).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS17035
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