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AQP3 / Aquaporin 3 Antibody (aa74-292)

Rabbit Polyclonal Antibody

     
  • IHC - AQP3 / Aquaporin 3 Antibody (aa74-292) ALS17039
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q92482
Other Accession 360
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 31544 Da
Dilution IHC-P (10 µg/ml),
Additional Information
Gene ID 360
Other Names AQP3, Aquaporin 3 (GIL blood group), Aquaglyceroporin-3, AQP-3, Aquaporin 3, Aquaporin 3 (Gill blood group), Aquaporin-3, GIL
Target/Specificity Human AQP3 / Aquaporin 3
Reconstitution & Storage PBS, pH 7, 20% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsAQP3 / Aquaporin 3 Antibody (aa74-292) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQP3
Function Water channel required to promote glycerol permeability and water transport across cell membranes (PubMed:12239222, PubMed:30420639). Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47862}. Basolateral cell membrane {ECO:0000250|UniProtKB:P47862}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47862}
Tissue Location Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).

References

Ishibashi K.,et al.Genomics 27:352-354(1995).
Ishibashi K.,et al.Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
Roudier N.,et al.J. Biol. Chem. 277:45854-45859(2002).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS17039
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