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VAMP2 / VAMP-2 Antibody (aa1-66)

Rabbit Polyclonal Antibody

     
  • IHC - VAMP2 / VAMP-2 Antibody (aa1-66) ALS17042
    Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • WB - VAMP2 / VAMP-2 Antibody (aa1-66) ALS17042
    Anti-VAMP2 antibody used in Western blot at 1:90000 dilution to detect 100ng of 19kDa...
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P63027
Other Accession 6844
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 12663 Da
Dilution IHC-P (5 µg/ml),
Additional Information
Gene ID 6844
Other Names VAMP2, SYB2, Synaptobrevin 2, VAMP-2, Synaptobrevin-2
Target/Specificity Human VAMP2 / VAMP-2
Reconstitution & Storage 0.1 M Tris-glycine, pH 7, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsVAMP2 / VAMP-2 Antibody (aa1-66) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VAMP2 (HGNC:12643)
Synonyms SYB2
Function Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell membrane {ECO:0000250|UniProtKB:P63045}. Note=Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651)
Tissue Location Nervous system and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

References

Archer B.T. III,et al.J. Biol. Chem. 265:17267-17273(1990).
Nabokina S.M.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Taruscio D.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS17042
Size:

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