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FBLN4 / EFEMP2 Antibody (aa91-140)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | O95967 |
| Other Accession | 30008 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 49405 Da |
| Dilution | ELISA (1:10000), IF (1:100 - 1:500), IHC-P (1:100), WB (1:500 - 1:1000), |
| Gene ID | 30008 |
|---|---|
| Other Names | EFEMP2, ARCL1B, FIBL-4, Fibulin-4, Fibulin 4, Protein UPH1, MBP1, UPH1, FBLN4, Mutant p53 binding protein 1 |
| Target/Specificity | EFEMP2 Antibody detects endogenous levels of total EFEMP2 protein. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | FBLN4 / EFEMP2 Antibody (aa91-140) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EFEMP2 (HGNC:3219) |
|---|---|
| Synonyms | FBLN4 |
| Function | Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta (PubMed:27339457). In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (By similarity). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction (PubMed:18973305, PubMed:19570982). Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling (PubMed:23782690). |
| Cellular Location | Secreted, extracellular space, extracellular matrix Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:Q9WVJ9}. Note=Localizes on the microfibrils surrounding ELN cores. {ECO:0000250|UniProtKB:Q9WVJ9} |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Giltay R.,et al.Matrix Biol. 18:469-480(1999).
Zemel R.,et al.Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
Katsanis N.,et al.Hum. Genet. 106:66-72(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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