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FH / Fumarase / MCL Antibody (clone 9G4)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, Flo |
|---|---|
| Primary Accession | P07954 |
| Other Accession | 2271 |
| Reactivity | Human, Rat, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 9G4 |
| Calculated MW | 54637 Da |
| Dilution | Flo (1:100), IF (1:100), IHC-P (10 µg/ml), WB (1:1000), |
| Gene ID | 2271 |
|---|---|
| Other Names | FH, Fumarase, Fumarate hydratase, MCUL1, HLRCC, LRCC, MCL |
| Target/Specificity | Human FH / Fumarase |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | FH / Fumarase / MCL Antibody (clone 9G4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FH {ECO:0000303|PubMed:27037871, ECO:0000312|HGNC:HGNC:3700} |
|---|---|
| Function | Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). |
| Cellular Location | [Isoform Mitochondrial]: Mitochondrion |
| Tissue Location | Expressed in red blood cells; underexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Also acts as a tumor suppressor.
References
Gellera C.,et al.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
Bourgeron T.,et al.Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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