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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VDAC1 / PORIN Antibody   

VDAC1 / PORIN Antibody

Rabbit Polyclonal Antibody

     
  • IHC - VDAC1 / PORIN Antibody ALS17058
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - VDAC1 / PORIN Antibody ALS17058
    Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - VDAC1 / PORIN Antibody ALS17058
    western blot analysis of hepg2 cell lysates wirh anti-vdac1 antibody
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P21796
Other Accession 7416
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 30773 Da
Dilution ELISA (1:20000), IHC-P (5 µg/ml), WB (1:250),
Additional Information
Gene ID 7416
Other Names VDAC1, HVDAC1, Plasmalemmal porin, Porin 31HM, PORIN, PORIN-31-HL, Vdac5, VDAC, Mitochondrial porin, Porin 31HL, VDAC-1
Target/Specificity VDAC1 antibody detects endogenous levels of VDAC1 protein. Not tested with other proteins.
Reconstitution & Storage PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.
PrecautionsVDAC1 / PORIN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VDAC1
Synonyms VDAC
Function Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).
Cellular Location Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Membrane raft; Multi-pass membrane protein
Tissue Location Heart, liver and skeletal muscle.
Research Areas
Citations (0)

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Background

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

References

Blachly-Dyson E.,et al.J. Biol. Chem. 268:1835-1841(1993).
Blachly-Dyson E.,et al.Biophys. J. 59:216A-216A(1991).
Decker W.K.,et al.Mamm. Genome 10:1041-1042(1999).
Messina A.,et al.Biochem. Biophys. Res. Commun. 270:787-792(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS17058
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