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O3FAR1 / GPR120 Antibody (aa226-284)

Rabbit Polyclonal Antibody

     
  • IHC - O3FAR1 / GPR120 Antibody (aa226-284) ALS17062
    Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - O3FAR1 / GPR120 Antibody (aa226-284) ALS17062
    Western blot analysis of GPR120 Antibody at 1:500 dilution.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q5NUL3
Other Accession 338557
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 42241 Da
Dilution IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 338557
Other Names FFAR4, Free fatty acid receptor 4, GT01, GPR129, GPR120, O3FAR1, PGR4, BMIQ10
Target/Specificity Human O3FAR1 / GPR120
Reconstitution & Storage PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsO3FAR1 / GPR120 Antibody (aa226-284) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FFAR4
Synonyms GPR120, GPR129, O3FAR1, PGR4
Function Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Colocalized with ARRB2 following DHA treatment.
Tissue Location Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

References

Fredriksson R.,et al.FEBS Lett. 554:381-388(2003).
Hirasawa A.,et al.Nat. Med. 11:90-94(2005).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Vassilatis D.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).

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$ 395.00
Cat# ALS17062
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