|Application ||WB, IHC-P|
|Calculated MW||36566 Da|
|Dilution||IHC-P (5 µg/ml),|
|Other Names||SRR, D-serine dehydratase, ISO1, L-serine ammonia-lyase, L-serine dehydratase, ILV1, Serine racemase, D-serine ammonia-lyase|
|Target/Specificity||Human SRR / Serine Racemase|
|Reconstitution & Storage||0.1 M Tris-glycine, pH 7, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||SRR / Serine Racemase Antibody (aa131-340) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.|
|Tissue Location||Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver|
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Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
De Miranda J.,et al.Gene 256:183-188(2000).
Xia M.,et al.Brain Res. Mol. Brain Res. 125:96-104(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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