SOX13 Antibody (aa75-520)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC, IP |
---|---|
Primary Accession | Q9UN79 |
Other Accession | 9580 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 69228 Da |
Dilution | ICC (1:100 - 1:1000), IHC-P (5 µg/ml), IP (1:100 - 1:500), WB (1:500 - 1:3000), |
Gene ID | 9580 |
---|---|
Other Names | SOX13, ICA12, Islet cell antibody 12, SRY-box 13, SRY-related HMG-box gene 13, Sox-13, Transcription factor SOX-13, Islet cell antigen 12 |
Target/Specificity | Human SOX13 |
Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | SOX13 Antibody (aa75-520) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SOX13 |
---|---|
Function | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Cytoplasm |
Tissue Location | Expressed in exocrine cells and islets of Langerhans in the pancreas (at protein level) (PubMed:10871192) Expressed in the pancreas, placenta, kidney, brain, heart, lung, and liver (PubMed:10871192, PubMed:20028982). Expressed in adipose tissue, cervix, colon, esophagus, ovary, prostate, small intestine, spleen, testicle, thymus and thyroid (PubMed:20028982) |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to the sequence 5'-AACAAT-3'.
References
Roose J.,et al.Nucleic Acids Res. 26:469-476(1998).
LaGasse J.M.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Kasimiotis H.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Argentaro A.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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