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SOX13 Antibody (aa75-520)

Rabbit Polyclonal Antibody

     
  • IHC - SOX13 Antibody (aa75-520) ALS17069
    Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • ICC - SOX13 Antibody (aa75-520) ALS17069
    Immunofluorescence of paraformaldehyde-fixed HeLa using SOX13 antibody at 1:200 dilution.
    detail
  • WB - SOX13 Antibody (aa75-520) ALS17069
    Sample (30 ug of whole cell lysate). A: Molt-4 . 7.5% SDS PAGE. SOX13 antibody diluted at 1:1000.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, IP
Primary Accession Q9UN79
Other Accession 9580
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 69228 Da
Dilution ICC (1:100 - 1:1000), IHC-P (5 µg/ml), IP (1:100 - 1:500), WB (1:500 - 1:3000),
Additional Information
Gene ID 9580
Other Names SOX13, ICA12, Islet cell antibody 12, SRY-box 13, SRY-related HMG-box gene 13, Sox-13, Transcription factor SOX-13, Islet cell antigen 12
Target/Specificity Human SOX13
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsSOX13 Antibody (aa75-520) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX13
Function Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Cytoplasm
Tissue Location Expressed in exocrine cells and islets of Langerhans in the pancreas (at protein level) (PubMed:10871192) Expressed in the pancreas, placenta, kidney, brain, heart, lung, and liver (PubMed:10871192, PubMed:20028982). Expressed in adipose tissue, cervix, colon, esophagus, ovary, prostate, small intestine, spleen, testicle, thymus and thyroid (PubMed:20028982)
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Binds to the sequence 5'-AACAAT-3'.

References

Roose J.,et al.Nucleic Acids Res. 26:469-476(1998).
LaGasse J.M.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Kasimiotis H.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Argentaro A.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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Discontinued
Cat# ALS17069
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