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F2 / Prothrombin / Thrombin Antibody

Sheep Polyclonal Antibody

     
  • IHC - F2 / Prothrombin / Thrombin Antibody ALS17072
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - F2 / Prothrombin / Thrombin Antibody ALS17072
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, IE
Primary Accession P00734
Other Accession 2147
Reactivity Human
Host Sheep
Clonality Polyclonal
Isotype IgG
Calculated MW 70037 Da
Dilution IHC-P (1:100),
Additional Information
Gene ID 2147
Other Names F2, Prothrombin B-chain, Coagulation factor II, FACTOR II, Prothrombin, PT, RPRGL2, Serine protease, THPH1, Thrombin
Target/Specificity Recognizes human Prothrombin.
Reconstitution & Storage 0.01 M HEPES, pH 7.4, 150mM sodium chloride, 50% glycerol. No preservative added. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsF2 / Prothrombin / Thrombin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name F2
Function Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Cellular Location Secreted, extracellular space.
Tissue Location Expressed by the liver and secreted in plasma.
Volume 250 µl
Research Areas
Citations (0)

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Background

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

References

Degen S.J.F.,et al.Biochemistry 26:6165-6177(1987).
Wang W.,et al.Haemophilia 10:94-97(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Degen S.J.F.,et al.Biochemistry 22:2087-2097(1983).

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$ 395.00
Cat# ALS17072
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