|Application ||IHC-P, E, IE|
|Calculated MW||70037 Da|
|Other Names||F2, Prothrombin B-chain, Coagulation factor II, FACTOR II, Prothrombin, PT, RPRGL2, Serine protease, THPH1, Thrombin|
|Target/Specificity||Recognizes human Prothrombin.|
|Reconstitution & Storage||0.01 M HEPES, pH 7.4, 150mM sodium chloride, 50% glycerol. No preservative added. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||F2 / Prothrombin / Thrombin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Degen S.J.F.,et al.Biochemistry 26:6165-6177(1987).
Wang W.,et al.Haemophilia 10:94-97(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Degen S.J.F.,et al.Biochemistry 22:2087-2097(1983).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.